Nat Rev Mol Cell Biol. 2001 Feb;2(2):138-45.

Filamins as integrators of cell mechanics and signalling.

Stossel TP, Condeelis J, Cooley L, Hartwig JH, Noegel A, Schleicher M, Shapiro SS.

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Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. tstossel@rics.bwh.harvard.edu

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

PMID:: 11252955; [PubMed - indexed for MEDLINE]

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Review Filamins in cell signaling, transcription and organ development. [Trends Cell Biol. 2010]
Review Filamins in cell signaling, transcription and organ development.
Zhou AX, Hartwig JH, Akyürek LM. Trends Cell Biol. 2010 Feb; 20(2):113-23. Epub 2010 Jan 12.
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Cited by over 100 PubMed Central articles

Filamin and Phospholipase C-ε Are Required for Calcium Signaling in the Caenorhabditis elegans Spermatheca. [PLoS Genet. 2013]
Filamin and Phospholipase C-ε Are Required for Calcium Signaling in the Caenorhabditis elegans Spermatheca.
Kovacevic I, Orozco JM, Cram EJ. PLoS Genet. 2013 May; 9(5):e1003510. Epub 2013 May 9.
Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function. [Sci Rep. 2013]
Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function.
Chen H, Chandrasekar S, Sheetz MP, Stossel TP, Nakamura F, Yan J. Sci Rep. 2013 Apr 10; 3:1642.
Investigation of radiation-induced transcriptome profile of radioresistant non-small cell lung cancer A549 cells using RNA-seq. [PLoS One. 2013]
Investigation of radiation-induced transcriptome profile of radioresistant non-small cell lung cancer A549 cells using RNA-seq.
Yang HJ, Kim N, Seong KM, Youn H, Youn B. PLoS One. 2013; 8(3):e59319. Epub 2013 Mar 22.

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