Nat Rev Mol Cell Biol. 2001 Feb;2(2):138-45.

Filamins as integrators of cell mechanics and signalling.

Stossel TP, Condeelis J, Cooley L, Hartwig JH, Noegel A, Schleicher M, Shapiro SS.

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Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. tstossel@rics.bwh.harvard.edu

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

PMID:: 11252955; [PubMed - indexed for MEDLINE]

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