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Nat Rev Mol Cell Biol. 2000 Dec;1(3):179-86.

The many substrates and functions of ATM.

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  • 1Department of Hematology-Oncology, Saint Jude Children's Research Hospital, D1034, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA. michael.kastan@stjude.org


As its name suggests, the ATM--'ataxia-telangiectasia, mutated'--gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.

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