Nat Rev Mol Cell Biol. 2000 Dec;1(3):169-78.

How cells read TGF-beta signals.

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Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, Box 116, 1275 York Avenue, New York, New York 10021, USA. j-massague@ski.mskcc.org

Abstract

Cell proliferation, differentiation and death are controlled by a multitude of cell-cell signals, and loss of this control has devastating consequences. Prominent among these regulatory signals is the transforming growth factor-beta (TGF-beta) family of cytokines, which can trigger a bewildering diversity of responses, depending on the genetic makeup and environment of the target cell. What are the networks of cell-specific molecules that mould the TGF-beta response to each cell's needs?

PMID:: 11252892; [PubMed - indexed for MEDLINE]

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