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Evol Dev. 2000 May-Jun;2(3):166-73.

From phenotype to genotype.

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  • 1Department of Zoology and Program in Genetics, University of New Hampshire, Durham 03824, USA. jts3@hopper.unh.edu


Advances in the field of genomics have made it possible to decipher the genetic and transcriptional changes that underlie differences among organisms. Here we discuss the merits and drawbacks of these strategies as they relate to evolutionary biology. We suggest that the molecular basis of natural variation can best be interpreted via the intersection of genomic and transcriptome approaches. We outline how this might be accomplished in practice and assemble the components of a method to comprehend the evolutionary interplay between genotype and phenotype.

[PubMed - indexed for MEDLINE]
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