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Curr Opin Genet Dev. 2001 Apr;11(2):130-5.

Higher-order structure of chromatin and chromosomes.

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  • 1Biology Department, University of Massachusetts, Amherst 01003, USA.


The linear array of nucleosomes that comprises the primary structure of chromatin is folded and condensed to varying degrees in nuclei and chromosomes forming 'higher order structures'. We discuss the recent findings from novel experimental approaches that have yielded significant new information on the different hierarchical levels of chromatin folding and their functional significance.

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