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Exp Gerontol. 2001 Mar;36(3):537-45.

The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4.

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  • 1Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA. jturner@cvmbs.colostate.edu

Abstract

The aging process is associated with alterations in the immune system. Some of the changes reported are an increase in the proportion of B lymphocytes, and a shift to a TH2-like cytokine environment. It has been hypothesized that the development of immunopathology within the lung during tuberculosis is linked to increased interleukin-4 (IL-4) production. In addition, a role for B cells in maintaining granuloma integrity has been recently proposed. This study investigated the role of B cells and IL-4 during the long-term course of chronic tuberculosis in mice and showed that the course of Mycobacterium tuberculosis infection in the lungs was not influenced by the absence of B lymphocytes or the TH2 cytokine IL-4.

PMID:
11250124
[PubMed - indexed for MEDLINE]
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