Curr Opin Mol Ther. 1999 Feb;1(1):121-5.

Technology evaluation: HIVAC-1e.

Source

St Bartholomew's Hospital, Dept of Immunology, University of London, 38 Little Britain, London, UK. r.q.zheng@mds.qmw.ac.uk

Abstract

Bristol-Myers Squibb is developing a vaccine, HIVAC-1e, comprised of a recombinant vaccinia virus expressing the HIV-1 gp160 envelope glycoprotein. The vaccine has potential for the treatment of HIV and other viral infections and has entered phase I trials [135333]. In an initial phase I trial, 11 vaccinia-naïve volunteers were vaccinated with HIVAC-1e, followed by a booster with baculovirus-derived gp160 (VaxSyn). Two weeks after boosting, all 11 volunteers developed HIV-1 specific IgG, with titers of 1:40 to 1:1280 [195287]. Using the same strategy in 29 vaccinia-naïve volunteers, priming with HIVAC-1e was demonstrated as a key determinant of the epitope specificity and magnitude of antibody responses to gp160 [195278].

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Serum antibodies to HIV-1 in recombinant vaccinia virus recipients boosted with purified recombinant gp160. NIAID AIDS Vaccine Clinical Trials Network. [J Clin Immunol. 1992]
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