Am J Hum Genet. 1975 Mar;27(2):218-23.

Half chromatid mutations: transmission in humans?

Abstract

Attention is drawn to the possibility of half chromatid and early somatic mutations and to several implications of these mosaic-yielding events. There is suggestive evidence that spontaneous mutations can result in mosaics. A world-wide cooperative study of Lesch-Nyhan families could determine the extent of half chromatid mutation transmission and early somatic mutation in humans.

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