Trends Biochem Sci. 2001 Mar;26(3):186-90.

I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations.

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German Cancer Research Center (DKFZ), Dept of Immunochemistry (G0200), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. L.Schmitz@DKFZ.de

Abstract

Activation of the transcription factor nuclear factor kappa B (NF-kappa B) requires its release from inhibitor of NF-kappa B (I kappa B) proteins in the cytoplasm. Much work has focussed on the identification of pathways regulating this cytosolic rate-limiting step of NF-kappa B activation. However, there is increasing evidence for another complex level of NF-kappa B activation, which involves modulatory phosphorylations of the DNA-binding subunits. These phosphorylations can control several functions of NF-kappa B, including DNA binding and transactivation properties, as well as interactions between the transcription factor and regulatory proteins. Although their overall impact on NF-kappa B function has yet to be determined, modifications of this factor will very probably provide a mechanism to fine tune NF-kappa B function.

PMID:: 11246025; [PubMed - indexed for MEDLINE]

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