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Trends Biochem Sci. 2001 Mar;26(3):167-74.

HMG1 and 2, and related 'architectural' DNA-binding proteins.

Author information

  • 1Cambridge Centre for Molecular Recognition, University of Cambridge, 80 Tennis Court Road, Cambridge, UK CB2 1GA.

Erratum in

  • Trends Biochem Sci 2001 Apr;26(4):219.


The HMG-box proteins, one of the three classes of high mobility group (HMG) chromosomal proteins, bend DNA and bind preferentially to distorted DNA structures. The proteins appear to act primarily as architectural facilitators in the assembly of nucleoprotein complexes; for example, in effecting recombination and in the initiation of transcription. HMG-box proteins might be targeted to particular DNA sites in chromatin by either protein-protein interactions or recognition of specific DNA structures.

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