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1: J Pain Symptom Manage. 2001 Mar;21(3):255-64.Click here to read Links

Opioid poorly-responsive cancer pain. Part 2: basic mechanisms that could shift dose response for analgesia.

Mercadante S, Portenoy RK.

Anesthesia and Intensive Care Unit & Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy.

Basic research in experimental pain models may illuminate the phenomenon of cancer pain that is poorly responsive to opioid drugs. Research findings can be valuable in formulating new strategies in clinical practice. This review evaluated experimental observations in terms of the events that occur in cancer patients receiving opioid therapy for pain.

PMID: 11239748 [PubMed - indexed for MEDLINE]