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Clin Biochem. 2001 Feb;34(1):23-7.

Monitoring xenotransplant recipients for infection by PERV.

Author information

  • 1Porcine Endogenous Retrovirus Research Group, Imutran Ltd (A Novartis Pharma AG Co), PO Box 399, CB2 2YP, Cambridge, UK. Chris.herring@pharma.novartis.com

Abstract

OBJECTIVES:

Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus (PERV) to porcine xenograft recipients.

METHODS:

To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell microchimerism have been developed by a number of groups. Retrospective studies of patients exposed to living pig tissues have been performed using these assays to look for evidence of cross species transmission.

RESULTS:

To date no evidence of PERV infection has been found in studies of humans exposed to pig tissues, despite evidence of long lived microchimerism.

CONCLUSIONS:

These data suggest that PERV infection has not occurred in a clinical setting. However, as infection has been seen in a small animal model further investigation of the risk from PERV is warranted.

PMID:
11239511
[PubMed - indexed for MEDLINE]
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