Therapie. 2000 Nov-Dec;55(6):699-704.

[Delayed drug-induced hepatic injury. Evoking the role of amoxicillin-clavulinic acid combination].

[Article in French]

Source

Centre Régional de Pharmacovigilance de Saint-Etienne, Hôpital de Bellevue, CHU de Saint-Etienne, 42055 Saint-Etienne, France.

Abstract

Although infrequent, hepatitis associated with amoxicillin and clavulanic acid combination is probably underestimated. Except for cases with few symptoms, a time interval between stopping treatment and the first manifestations (jaundice in most cases), sometimes of several weeks, may hinder diagnosis. We report 9 patients who exhibited this characteristic. The delay between stopping treatment and the onset of hepatitis varied from 13 days to 6 weeks after stopping the drug. Other causes of jaundice were excluded. Male sex, advancing age, or prolonged treatment (more than 10 days) may increase the risk. Complete recovery occurs within 1 to 4 months after discontinuation of treatment. The mechanism is unclear. Clinical and biological signs of hypersensitivity may suggest an immunoallergic reaction.

PMID:: 11234465; [PubMed - indexed for MEDLINE]

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