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Nat Med. 2001 Mar;7(3):297-303.

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming.

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  • 1Immunology Unit, Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France.

Abstract

The initiation of T-cell-mediated antitumor immune responses requires the uptake and processing of tumor antigens by dendritic cells and their presentation on MHC-I molecules. Here we show in a human in vitro model system that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells. After mouse tumor exosome uptake, dendritic cells induce potent CD8+ T-cell-dependent antitumor effects on syngeneic and allogeneic established mouse tumors. Therefore, exosomes represent a novel source of tumor-rejection antigens for T-cell cross priming, relevant for immunointerventions.

PMID:
11231627
[PubMed - indexed for MEDLINE]
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