Biol Psychiatry. 2001 Feb 1;49(3):258-67.

Cognitive effects of nicotine.

Source

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.

Abstract

Nicotine and other nicotinic agonists have been found to improve performance on attention and memory tasks. Clinical studies using nicotine skin patches have demonstrated the efficacy of nicotine in treating cognitive impairments associated with Alzheimer's disease, schizophrenia, and attention-deficit/hyperactivity disorder. Experimental animal studies have demonstrated the persistence of nicotine-induced working memory improvement with chronic exposure, in addition to the efficacy of a variety of nicotinic agonists. Mechanistic studies have found that alpha7 and alpha4beta2 nicotinic receptors in the hippocampus are critical for nicotinic involvement in cognitive function. Clinical and experimental animal studies provide mutually supporting information for the development of novel nicotinic therapies for cognitive dysfunction.

PMID:: 11230877; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

DA 11943/DA/NIDA NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Alzheimer's Disease - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Development of nicotinic drug therapy for cognitive disorders. [Eur J Pharmacol. 2000]
Development of nicotinic drug therapy for cognitive disorders.
Levin ED, Rezvani AH. Eur J Pharmacol. 2000 Mar 30; 393(1-3):141-6.
Review Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization. [Psychopharmacology (Berl). 2006]
Review Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization.
Levin ED, McClernon FJ, Rezvani AH. Psychopharmacology (Berl). 2006 Mar; 184(3-4):523-39. Epub 2005 Oct 12.
Review Nicotinic treatment for cognitive dysfunction. [Curr Drug Targets CNS Neurol D...]
Review Nicotinic treatment for cognitive dysfunction.
Levin ED, Rezvani AH. Curr Drug Targets CNS Neurol Disord. 2002 Aug; 1(4):423-31.
Review Nicotinic receptor subtypes and cognitive function. [J Neurobiol. 2002]
Review Nicotinic receptor subtypes and cognitive function.
Levin ED. J Neurobiol. 2002 Dec; 53(4):633-40.
Review Nicotinic-antipsychotic drug interactions and cognitive function. [EXS. 2006]
Review Nicotinic-antipsychotic drug interactions and cognitive function.
Levin ED, Rezvani AH. EXS. 2006; 98:185-205.

See reviews... See all...

Cited by 44 PubMed Central articles

The visinin-like proteins VILIP-1 and VILIP-3 in Alzheimer's disease-old wine in new bottles. [Front Mol Neurosci. 2012]
The visinin-like proteins VILIP-1 and VILIP-3 in Alzheimer's disease-old wine in new bottles.
Braunewell KH. Front Mol Neurosci. 2012 Jan 19; 5:20. Epub 2012 Feb 23.
ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. [PLoS One. 2011]
ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.
Chen J, Brunzell DH, Jackson K, van der Vaart A, Ma JZ, Payne TJ, Sherva R, Farrer LA, Gejman P, Levinson DF, et al. PLoS One. 2011; 6(12):e28790. Epub 2011 Dec 20.
Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control. [Psychopharmacology (Berl). 2011]
Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control.
Wouda JA, Riga D, De Vries W, Stegeman M, van Mourik Y, Schetters D, Schoffelmeer AN, Pattij T, De Vries TJ. Psychopharmacology (Berl). 2011 Jul; 216(2):267-77. Epub 2011 Feb 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cognitive effects of nicotine.
Cognitive effects of nicotine.
Biol Psychiatry. 2001 Feb 1 ;49(3):258-67.

PubMed
Comparison between MR imaging and 99mTc MIBI scintigraphy in the evaluation of r...
Comparison between MR imaging and 99mTc MIBI scintigraphy in the evaluation of recurrent of persistent hyperparathyroidism.
Radiology. 2001 Mar ;218(3):783-90.

PubMed
Racial divergence in adiposity during adolescence: The NHLBI Growth and Health S...
Racial divergence in adiposity during adolescence: The NHLBI Growth and Health Study.
Pediatrics. 2001 Mar ;107(3):E34.

PubMed
Comparison of three nucleic acid amplification assays of cerebrospinal fluid for...
Comparison of three nucleic acid amplification assays of cerebrospinal fluid for diagnosis of cytomegalovirus encephalitis.
J Clin Microbiol. 2001 Mar ;39(3):1148-51.

PubMed
The dangers of aerosol sprays.
The dangers of aerosol sprays.
Eye Ear Nose Throat Mon. 1975 May ;54(5):211.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: