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Bioorg Med Chem Lett. 2001 Feb 26;11(4):483-5.

Evidence for gliotoxin-glutathione conjugate adducts.

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  • 1Department of Chemistry, The Faculties, Australian National University, ACT.

Abstract

The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200+/-100 M(-1) at pH 7.0 at 25 degrees C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.

PMID:
11229753
[PubMed - indexed for MEDLINE]
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