Curr Opin Immunol. 2001 Apr;13(2):134-40.

Immunity against cancer: lessons learned from melanoma.

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Memorial Sloan-Kettering Cancer Center and Weill Medical School of Cornell University, 1275 York Avenue, New York, NY 10021, USA. a-houghton@ski.mskcc.org

Abstract

Most major advances in human cancer immunology and immunotherapy have come from studies in melanoma. We are beginning to understand the immune repertoire of T cells and antibodies that are active against melanoma, with recent glimpses of the CD4(+) T cell repertoire. The view of what the immune system can see is extending to mutations and parts of the genome that are normally invisible.

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