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FEBS Lett. 2001 Feb 23;491(1-2):159-63.

Antibacterial activity of a pepsin-derived bovine hemoglobin fragment.

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  • 1Laboratoire de Technologie des Substances Naturelles, Institut Universitaire de Technologie, Département Génie Biologique, Université des Sciences et Technologie de Lille, PO Box 179, 59653 Villeneuve d'Ascq Cedex, France.

Abstract

Peptic digestion of bovine hemoglobin yields a fragment with antibacterial activity. This peptide was purified to homogeneity by a two-step procedure including anion exchange chromatography and preparative reversed-phase HPLC. Mass determination and fragmentation indicated that this peptide corresponded to the 1-23 fragment of the alpha chain of hemoglobin. The minimum inhibitory concentration and mode of action of this peptide towards Micrococcus luteus strain A270 were determined. Hemolytic assay, interaction with liposomes, and study of its structure in solution were also performed.

PMID:
11226440
[PubMed - indexed for MEDLINE]
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