Blood. 2001 Mar 1;97(5):1388-91.

CD4(+) cutaneous T-cell lymphoma cells express the p140-killer cell immunoglobulin-like receptor.

Bagot M, Moretta A, Sivori S, Biassoni R, Cantoni C, Bottino C, Boumsell L, Bensussan A.

Source

INSERM U448 and Service de Dermatologie de l'hopital Henri Mondor, Creteil, France. martine.bagot@hmn.ap-hop-paris.fr

Abstract

Tumor cells of patients with cutaneous T-cell lymphoma (CTCL) have the cell surface phenotype of mature T-helper lymphocytes, and it may be impossible to differentiate them from nonmalignant lymphocytes in skin and blood. Until now, no specific cell membrane marker of CTCL has been reported. In the current study, it is reported for the first time that CTCL cells express the major histocompatibility complex class I binding p140-killer cell immunoglobulin-like receptor, which has been described on a minor subset of natural killer lymphocytes and on a marginal circulating CD8(+) T lymphocyte subset. Interestingly, the molecular characterization of this KIR expressed by CTCL allowed us to isolate a novel allelic form of p140-KIR3DL, resulting in 4 amino acid substitutions, 3 in the extracellular immunoglobulin-like domain of the protein and one in the cytoplasmic region. This finding is likely to be important both for the pathophysiology and for the clinical treatment of patients with CTCL.

PMID:: 11222384; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Lymphoma - MedlinePlus Health Information

Supplemental Content

Related citations

Killer cell immunoglobulin-like receptor expression delineates in situ Sézary syndrome lymphocytes. [J Pathol. 2003]
Killer cell immunoglobulin-like receptor expression delineates in situ Sézary syndrome lymphocytes.
Wechsler J, Bagot M, Nikolova M, Parolini S, Martin-Garcia N, Boumsell L, Moretta A, Bensussan A. J Pathol. 2003 Jan; 199(1):77-83.
Tumor-specific peptides in cutaneous T-cell lymphoma: association with class I major histocompatibility complex and possible derivation from the clonotypic T-cell receptor. [Int J Cancer. 1998]
Tumor-specific peptides in cutaneous T-cell lymphoma: association with class I major histocompatibility complex and possible derivation from the clonotypic T-cell receptor.
Berger CL, Longley BJ, Imaeda S, Christensen I, Heald P, Edelson RL. Int J Cancer. 1998 May 4; 76(3):304-11.
Review Identification of cell surface molecules characterizing human cutaneous T-cell lymphomas. [Leuk Lymphoma. 2002]
Review Identification of cell surface molecules characterizing human cutaneous T-cell lymphomas.
Nikolova M, Bagot M, Boumsell L, Bensussan A. Leuk Lymphoma. 2002 Apr; 43(4):741-6.
Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling. [Blood. 2002]
Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling.
Nikolova M, Musette P, Bagot M, Boumsell L, Bensussan A. Blood. 2002 Aug 1; 100(3):1019-25.
Review Cutaneous T cell lymphoma: the helping hand of dendritic cells. [Ann N Y Acad Sci. 2001]
Review Cutaneous T cell lymphoma: the helping hand of dendritic cells.
Edelson RL. Ann N Y Acad Sci. 2001 Sep; 941:1-11.

See reviews... See all...

Cited by 1 PubMed Central article

CD158K/KIR3DL2 transcript detection in lesional skin of patients with erythroderma is a tool for the diagnosis of Sézary syndrome. [J Invest Dermatol. 2008]
CD158K/KIR3DL2 transcript detection in lesional skin of patients with erythroderma is a tool for the diagnosis of Sézary syndrome.
Ortonne N, Le Gouvello S, Mansour H, Poillet C, Martin N, Delfau-Larue MH, Leroy K, Farcet JP, Bagot M, Bensussan A. J Invest Dermatol. 2008 Feb; 128(2):465-72. Epub 2007 Aug 16.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

CD4(+) cutaneous T-cell lymphoma cells express the p140-killer cell immunoglobul...
CD4(+) cutaneous T-cell lymphoma cells express the p140-killer cell immunoglobulin-like receptor.
Blood. 2001 Mar 1 ;97(5):1388-91.

PubMed
Two screening tests for urinary voiding dysfunction used in 209 consecutive pati...
Two screening tests for urinary voiding dysfunction used in 209 consecutive patients undergoing lumbar spine operations.
Scand J Urol Nephrol. 2010 Mar ;44(2):106-12.

PubMed
Acquisition of antibodies to merozoite surface protein 3 among residents of Koro...
Acquisition of antibodies to merozoite surface protein 3 among residents of Korogwe, north eastern Tanzania.
BMC Infect Dis. 2010 Mar 8 ;10:55.

PubMed
Anticonvulsant medications in the pediatric emergency room and intensive care un...
Anticonvulsant medications in the pediatric emergency room and intensive care unit.
Pediatr Emerg Care. 2008 Oct ;24(10):705-18; quiz 719-21.

PubMed
[KIR3DL2: a new step for the management of patients with Sezary syndrome].
[KIR3DL2: a new step for the management of patients with Sezary syndrome].
Med Sci (Paris). 2006 Aug-Sep ;22(8-9):691-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

CD4(+) cutaneous T-cell lymphoma cells express the p140-killer cell immunoglobulin-like receptor.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information