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Lancet. 2001 Jan 27;357(9252):280-1.

Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection.

Abstract

In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-alpha plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected patients already treated with nucleoside analogues, leading to clinical deterioration in some cases.

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PMID:
11214134
[PubMed - indexed for MEDLINE]
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