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Neurol Sci. 2000;21(4 Suppl 2):S843-7.

Is multiple sclerosis severity a genetically influenced trait?

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  • 1Department of Neuroscience, University of Cagliari, Multiple Sclerosis Center, Ospedale Binaghi, Italy.


Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system of unknown pathogenesis, is a complex disease with a multifactorial etiology determined by both genetic and environmental factors. The pathological entity MS has a wide phenotype, and also the severity of the disease is widely variable. Clinical heterogeneity of the disease might arise from different genotype-phenotype interactions. Results of recent studies and theories about the modifying role of different genes in the course and the severity of MS are here discussed.

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