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Anticancer Res. 2000 Nov-Dec;20(6B):4571-8.

Prognostic value of E-cadherin, beta-catenin, P120ctn in patients with transitional cell bladder cancer.

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  • 1Department of Pathology, Medical School, University of Athens, 75 Mikras Assias Str., Athens GR-115 27, Greece. lnakopou@cc.uoa.gr

Abstract

BACKGROUND:

Loss of E-cadherin-catenin mediated adhesion is known to play a major role in tumour progression in many human carcinomas.

MATERIALS AND METHODS:

By means of immunohistochemistry, we have investigated the expression of E-cadherin, beta-catenin and p120ctn in 102 transitional cell bladder carcinomas (TCCs) and statistically analysed these expressions with known clinicopathological parameters and patient survival.

RESULTS:

Abnormal expression of E-cadherin, beta-catenin and p120ctn was associated with high grade and high stage of TCCs (p < 0.001). Abnormal beta-catenin expression demonstrated a statistically significant correlation with poor patient survival (p = 0.03) while abnormal E-cadherin expression was associated with poor survival in patients with muscle invasive TCCs (p = 0.025). However, in multivariate statistical analysis a suggestive association with poor survival was observed only for E-cadherin (p = 0.06). Simultaneous abnormal expression of all the molecules demonstrated an association of suggestive significance with poor patient survival (p = 0.07).

CONCLUSION:

E-cadherin expression may be a useful prognostic marker in patients with invasive TCCs.

PMID:
11205306
[PubMed - indexed for MEDLINE]
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