Abstract
Experimental infection of colostrum-deprived (CD) pigs with a combined inoculum of porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiated the replication and distribution of PCV2 virus, when compared with pigs inoculated with PCV2 alone. The replication and distribution of PRRSV in dually infected pigs was not enhanced, when compared to pigs inoculated with PRRSV alone. The mechanisms involved in the potentiation of PCV2 replication in PCV2/PRRSV and PCV2/porcine parvovirus (PPV) dually infected pigs may relate to the fact that monocyte/macrophage cell types are common targets of these 3 viruses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Antibodies, Viral / blood
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Antigens, Viral / analysis
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Circoviridae Infections / complications
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Circoviridae Infections / veterinary*
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Circoviridae Infections / virology
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Circovirus / immunology
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Circovirus / isolation & purification
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Circovirus / physiology*
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Colostrum / immunology
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Fluorescent Antibody Technique
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Porcine Reproductive and Respiratory Syndrome / virology*
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Porcine respiratory and reproductive syndrome virus / immunology
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Porcine respiratory and reproductive syndrome virus / isolation & purification
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Porcine respiratory and reproductive syndrome virus / physiology*
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Random Allocation
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Swine
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Swine Diseases / virology*
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Virus Replication*
Substances
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Antibodies, Viral
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Antigens, Viral