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    Int J Med Microbiol. 2000 Dec;290(7):571-7.

    Staphylococcal surface display and its applications.

    Source

    Department of Biotechnology, Kungliga Tekniska Högskolan, Stockholm, Sweden. stefans@biochem.kth.se

    Abstract

    Novel surface proteins can be introduced onto the bacterial cell surface by recombinant means. Here, we describe the development of such display systems for two food-grade bacteria, Staphylococcus carnosus and Staphylococcus xylosus, and present how such engineered bacteria can be used in different applications. A study will be described in which such staphylococci were employed as vaccine delivery vehicles to elicit protective antibody responses to respiratory syncytial virus (RSV). The use of surface-engineered staphylococci as novel microbial biocatalysts, as a new type of whole-cell diagnostic devices or for adsorption of metal ions with potential environmental or biosensor applications, will also be discussed.

    PMID:
    11200538
    [PubMed - indexed for MEDLINE]

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