Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Neuroimaging. 2001 Jan;11(1):30-9.

Modeling of receptor ligand data in PET and SPECT imaging: a review of major approaches.

Author information

  • 1PET Imaging Centre, 11th floor, Clarke Division, CAMH, 250 College St., Department of Psychiatry, University of Toronto, Ontario, Canada M5T 1R8.

Abstract

Over the past decade, a number of new kinetic modeling techniques have been developed for PET and SPECT ligands. This article will review commonly used modeling solutions for reversible positron-emission tomography (PET) and single photon emission computed tomography (SPECT) radioligands, with an emphasis on noninvasive methods. All of the modeling approaches in PET and SPECT assume a compartmental system and derive parameters that describe the compartmental system. These parameters will be defined, and their relationship to analogous parameters in pharmacology will be discussed. Then the major approaches are presented under the categories of graphical or mathematical as well as invasive or noninvasive.

PMID:
11198524
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Write to the Help Desk