Send to:

Choose Destination
See comment in PubMed Commons below
J Anat. 2000 Nov;197 Pt 4:571-4.

Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT).

Author information

  • 1Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands.


Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3'-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk