[Aminosalicylates and aspirin for colonic cancer: from anti-inflammatory to antineoplastic drugs?]
[Article in German]
Abteilung Krebsnachsorge, Rehaklinik Ob der Tauber der LVA Württemberg, Akademisches Lehrkrankenhaus, Universität Heidelberg.
The aim of this article is to review potential antineoplastic properties of anti-inflammatory compounds commonly used in various inflammatory diseases such as aminosalicylates, aspirin and other nonsteroidal drugs. Starting from experimental and epidemiologic evidence showing prophylaxis and/or tumor regression/suppression, specific antineoplastic actions especially the inhibition of cyclooxygenase-(COX)dependent and COX-independent steps including the role of transcription factor (NFkappaB) in the cell cycle regulation are reviewed. In addition other mechanisms by which these drugs may exert antitumor effects, also may be important such as induction of apoptosis of cancer cells and/or inhibition of potentially carcinogenic oxidative DNA damage. Based on this knowledge potential clinical implications are discussed.
PMID: 11194887 [PubMed - indexed for MEDLINE]