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    Ann N Y Acad Sci. 2000;921:226-32.

    New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2.

    Drucker DJ, Lovshin J, Baggio L, Nian M, Adatia F, Boushey RP, Liu Y, Saleh J, Yusta B, Scrocchi L.

    Source

    Department of Medicine, Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada M5G2C4. d.drucker@utoronto.ca

    Abstract

    Glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) are coencoded within a single mammalian proglucagon precursor, and are liberated in the intestine and brain. GLP-1 exerts well known actions on islet hormone secretion, gastric emptying, and food intake. Recent studies suggest GLP-1 plays a central role in the development and organization of islet cells. GLP-1 receptor signaling appears essential for beta cell signal transduction as exemplified by studies of GLP-1R-/- mice. GLP-2 promotes energy assimilation via trophic effects on the intestinal mucosa of the small and large bowel epithelium via a recently cloned GLP-2 receptor. The actions of GLP-2 are preserved in the setting of small and large bowel injury and inflammation. The biological actions of the glucagon-like peptides suggest they may have therapeutic efficacy in diabetes (GLP-1) or intestinal disorders (GLP-2).

    PMID:
    11193827
    [PubMed - indexed for MEDLINE]

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