Ann N Y Acad Sci. 2000;924:1-7.

Genetic factors in the genesis of Alzheimer's disease.

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Department of Medicine (Division of Neurology), University Health Network, University of Toronto, Toronto, Ontario, Canada M5S 3H2. p.hyslop@utoronto.ca

Abstract

At least four different genes have been identified that are associated with inherited susceptibiltiy to Alzheimer's disease. Some of the genes are highly penetrant (PS1, PS2, beta APP); the other, APOE, is a weaker susceptibility factor. Several additional genes are suspected to exist but have not yet been cloned.

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