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    Science. 2000 Dec 22;290(5500):2271-3.

    Cell cycle. License withheld--geminin blocks DNA replication.

    Source

    Laboratory of General Biology, School of Medicine, University of Patras, 26110 Rio, Patras, Greece. z_lygerou@yahoo.com

    Abstract

    A cell ensures that its genome is replicated only once during its division cycle through a process called licensing. In an enlightening Perspective, Lygerou and Nurse explain how binding of the Geminin protein to Cdt1 blocks the binding of licensing factors to chromatin, inhibiting the onset of S phase (Wohlschlegel et al.).

    PMID:
    11188727
    [PubMed - indexed for MEDLINE]

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