Structure. 2000 Dec 15;8(12):R227-35.

Crawling and wiggling on DNA: structural insights to the mechanism of DNA unwinding by helicases.

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Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. k-marians@ski.mskcc.org

Abstract

Crystal structures have recently been solved of the monomeric DNA helicase PcrA bound to forked DNA, and of the hexameric helicase domain of the bacteriophage T7 gene 4 protein, a replication fork DNA helicase/primase. These structures have led to the elaboration of the first molecular models to describe DNA helicase action.

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