Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Ann Intern Med. 2001 Jan 2;134(1):25-9.

Diagnosis of primary HIV-1 infection. Los Angeles County Primary HIV Infection Recruitment Network.

Author information

  • 1Cedars-Sinai Burns & Allen Research Institute, University of California, Los Angeles, USA. Daar@CSHS.org

Abstract

BACKGROUND:

The optimal approach for diagnosing primary HIV-1 infection has not been defined.

OBJECTIVE:

To determine the usefulness of symptoms and virologic tests for diagnosing primary HIV-1 infection.

DESIGN:

Prospective cohort study.

SETTING:

A teaching hospital in Los Angeles and a university research center in San Diego, California.

PATIENTS:

436 patients who had symptoms consistent with primary HIV infection.

MEASUREMENTS:

Clinical information and levels of HIV antibody, HIV RNA, and p24 antigen.

RESULTS:

Primary infection was diagnosed in 54 patients (12.4%). The sensitivity and specificity of the p24 antigen assay were 88.7% (95% CI, 77.0% to 95.7%) and 100% (CI, 99.3% to 100%), respectively. For the HIV RNA assay, sensitivity was 100% and specificity was 97.4% (CI, 94.9% to 98.9%). Fever, myalgia, rash, night sweats, and arthralgia occurred more frequently in patients with primary infection (P < 0.05).

CONCLUSIONS:

No sign or symptom allows targeted screening for primary infection. Although assays for HIV RNA are more sensitive than those for p24 antigen in diagnosing primary infection, they are more expensive and are more likely to yield false-positive results.

Comment in

PMID:
11187417
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk