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1: Psychiatry Clin Neurosci. 2000 Jun;54(3):377-8.Click here to read Links

Effect of 3 mg melatonin on jet lag syndrome in an 8-h eastward flight.

Takahashi T, Sasaki M, Itoh H, Ozone M, Yamadera W, Hayshida K, Ushijima S, Matsunaga N, Obuchi K, Sano H.

Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan. tositaka@bd.mbn.or.jp

In order to assess the effect of melatonin on jet lag a field study was undertaken. The process of re-entrainment of circadian melatonin rhythm was investigated in six subjects. Except during 24-h blood sampling, the subjects were exposed to natural zeitgeber (time giver) outdoors and given 3 mg melatonin at 23:00 h. The subjects were exposed to bright sunlight from 3000 to 12000 lx. All of them showed orthodromic re-entrainment with taking melatonin, while two out of the six did not show orthodromic re-entrainment without taking melatonin. Melatonin accelerated the rate of the re-entrainment of the circadian melatonin rhythm. Melatonin was useful to jet travel from Tokyo to Los Angeles.

PMID: 11186121 [PubMed - indexed for MEDLINE]