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    Genome Biol. 2001;2(2):REVIEWS1005. Epub 2001 Jan 31.

    High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans.

    Bargmann CI.

    Howard Hughes Medical Institute, Departments of Anatomy and of Biochemistry and Biophysics, The University of California, San Francisco, CA 94143, USA. cori@itsa.ucsf.edu

    Two recent chromosome-wide screens for phenotypes caused by RNA-mediated interference (RNAi) in Caenorhabditis elegans have increased our understanding of essential genes in nematodes. These papers represent a major advance in functional genomics.

    PMID: 11182891 [PubMed - indexed for MEDLINE]

    PMCID: 138903

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