The complexity of simplicity. [Genome Biol. 2001]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Genome Biol. 2001;2(2):COMMENT2002. Epub 2001 Feb 8. Links

The complexity of simplicity.

Peterson SN, Fraser CM.

The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA. scottp@tigr.org

What is the minimum number of genes or functions necessary to support cellular life? The concept of a 'minimal genome' has become popular, but is it a useful concept, and if so, what might a minimal genome encode? We argue that the concept may be useful, even though the goal of defining a general minimal genome may never be attained.

PMID: 11182883 [PubMed - indexed for MEDLINE]

PMCID: PMC138898

ReviewHow many genes can make a cell: the minimal-gene-set concept.
Annu Rev Genomics Hum Genet. 2000; 1:99-116.

[Annu Rev Genomics Hum Genet. 2000]
ReviewMycoplasma genomics: tailoring the genome for minimal life requirements through reductive evolution.
Front Biosci. 2007 Jan 1; 12:2020-8. Epub 2007 Jan 1.

[Front Biosci. 2007]
The minimal genome paradox.
J Appl Genet. 2001; 42(3):385-92.

[J Appl Genet. 2001]
Essential genes of a minimal bacterium.
Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):425-30. Epub 2006 Jan 3.

[Proc Natl Acad Sci U S A. 2006]
Analysis of distribution indicates diverse functions of simple sequence repeats in Mycoplasma genomes.
Mol Biol Evol. 2006 Jul; 23(7):1370-85. Epub 2006 Apr 17.

[Mol Biol Evol. 2006]
» See reviews... | » See all...

Cited by 6 PubMed Central articles

Complete genome viral phylogenies suggests the concerted evolution of regulatory cores and accessory satellites.
de Andrade Zanotto PM, Krakauer DC. PLoS One. 2008; 3(10):e3500. Epub 2008 Oct 22.

[PLoS One. 2008]
Being pathogenic, plastic, and sexual while living with a nearly minimal bacterial genome.
Sirand-Pugnet P, Lartigue C, Marenda M, Jacob D, Barré A, Barbe V, Schenowitz C, Mangenot S, Couloux A, Segurens B, et al. PLoS Genet. 2007 May 18; 3(5):e75.

[PLoS Genet. 2007]
Tempo and mode of early gene loss in endosymbiotic bacteria from insects.
Delmotte F, Rispe C, Schaber J, Silva FJ, Moya A. BMC Evol Biol. 2006 Jul 18; 6:56. Epub 2006 Jul 18.

[BMC Evol Biol. 2006]
» See all...

Recent Activity

Clear Turn Off Turn On

The complexity of simplicity.The complexity of simplicity.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Display Show

The complexity of simplicity.

Related articles

Cited by 6 PubMed Central articles

Recent Activity