Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
    Biochem Biophys Res Commun. 2001 Feb 23;281(2):440-3.

    The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn).

    Source

    Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

    Abstract

    The human DF3/MUC1 glycoprotein is aberrantly overexpressed by carcinoma cells. The present studies show that MUC1 associates with the Armadillo protein, p120(ctn). The cytoplasmic domain of MUC1 binds directly to p120. The functional significance of the MUC1-p120 association is supported by the demonstration that MUC1 induces nuclear localization of p120. These findings demonstrate that MUC1 confers cell membrane to nuclear signaling by interactions with p120.

    Copyright 2001 Academic Press.

    PMID:
    11181067
    [PubMed - indexed for MEDLINE]

      Supplemental Content

      Icon for Elsevier Science

      Save items

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      Write to the Help Desk