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Genome Biol. 2001;2(1):REVIEWS3001. Epub 2001 Jan 9.

The ring-type polymerase sliding clamp family.

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  • 1Howard Hughes Medical Institute and Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. bruck@mod.rockefeller.edu


Ring-type polymerases consist of a DNA polymerase, a ring-shaped sliding clamp protein and a clamp-loading complex. Sliding clamp proteins are found in all organisms and are called proliferating cell nuclear antigen (PCNA) in eukaryotes and the beta clamp in prokaryotes. Both PCNA and beta form a ring around DNA, which is made up of two subunits of three domains each in beta but three subunits of two domains each in PCNA. Despite this difference and a lack of detectable sequence homology, the structures of the two rings are very similar. The sliding clamp slides along DNA and tethers the polymerase to the DNA, enabling rapid and processive DNA replication.

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