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Genome Biol. 2000;1(6):REVIEWS1030. Epub 2000 Dec 6.

Multiple RNA-protein interactions in Drosophila dosage compensation.

Author information

  • Department of Genetics, Duke University Medical Center, Research Drive, Durham, NC 27710, USA. hoa1@duke.edu

Abstract

From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males and females is achieved. Recent molecular genetic and biochemical studies have provided new insights into how regulatory factors in Drosophila are recruited and assembled on the X chromosome, leading to the essential hypertranscription of its genes.

PMID:
11178270
[PubMed - indexed for MEDLINE]
PMCID:
PMC138894
Free PMC Article

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