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1: Genome Biol. 2000;1(6):REVIEWS1030. Epub 2000 Dec 6.Click here to read Click here to read Links

Multiple RNA-protein interactions in Drosophila dosage compensation.

Amrein H.

Department of Genetics, Duke University Medical Center, Research Drive, Durham, NC 27710, USA. hoa1@duke.edu

From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males and females is achieved. Recent molecular genetic and biochemical studies have provided new insights into how regulatory factors in Drosophila are recruited and assembled on the X chromosome, leading to the essential hypertranscription of its genes.

PMID: 11178270 [PubMed - indexed for MEDLINE]

PMCID: PMC138894