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1: Genome Biol. 2000;1(4):REVIEWS1025. Epub 2000 Oct 13.Click here to read Click here to read Links

Secret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutation.

Maizels N.

Departments of Immunology and Biochemistry, University of Washington Medical School, 1959 NE Pacific Street, Seattle, WA 98195-7650, USA. maizels@u.washington.edu

A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.

PMID: 11178252 [PubMed - indexed for MEDLINE]

PMCID: PMC138873