An overview of the potassium channel family.
HHMI and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA. cmiller@brandeis.edu
Potassium channels, tetrameric integral membrane proteins that form aqueous pores through which K+ can flow, are found in virtually all organisms; the genomes of humans, Drosophila, and Caenorhabditis elegans contain 30-100 K+ channel genes each. The structure of a bacterial K+ channel, sequence comparisons with other channels and electrophysiological measurements have enabled conclusions about the mechanism of gating and ion flow to be drawn for many other channels.
PMID: 11178249 [PubMed - indexed for MEDLINE]
PMCID: PMC138870