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Genome Biol. 2000;1(2):REVIEWS1014. Epub 2000 Aug 2.

From lymphocytes to sharks: V(D)J recombinase moves to the germline.

Author information

  • Howard Hughes Medical Institute and Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA. davidbr@bcm.tmc.edu

Abstract

The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci.

PMID:
11178236
[PubMed - indexed for MEDLINE]
PMCID:
PMC138851
Free PMC Article

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