Format

Send to:

Choose Destination
See comment in PubMed Commons below
JAMA. 2001 Feb 14;285(6):755-60.

Survival and reproduction among males with birth defects and risk of recurrence in their children.

Author information

  • 1Section for Medical Statistics, University of Bergen, Armauer Hansens Bldg, 5021 Bergen, Norway. Rolv.Lie@smis.uib.no

Abstract

CONTEXT:

Few systematic data exist on survival and reproduction among males with birth defects and their contribution to occurrence of birth defects in the next generation.

OBJECTIVE:

To estimate survival of males with registered birth defects, their subsequent reproduction rates, and their risk of transmitting birth defects to their offspring.

DESIGN AND SETTING:

Population-based cohort study of data from the Medical Birth Registry of Norway.

SUBJECTS:

A total of 486 207 males born in Norway between 1967 and 1982, 12 292 of whom had a recorded birth defect.

MAIN OUTCOME MEASURES:

Survival rates through 1992, reproduction rates through 1998, and risk of birth defects among offspring of males with vs without birth defects.

RESULTS:

Survival through 1992 was lower among males with birth defects (84% vs 97%). Compared with males without birth defects, affected males were 28% less likely to have had a child. Among offspring of affected males, 5.1% had a registered birth defect compared with 2.1% of offspring of males without birth defects (relative risk [RR], 2.4; 95% confidence interval [CI], 1.9-3.0). Offspring of affected fathers had an increased risk of the same defect as their fathers (RR, 6.5; 95% CI, 4.0-10.4) and an increased risk of dissimilar defects (RR, 1.8; 95% CI, 1.3-2.5).

CONCLUSIONS:

Compared with unaffected males, males with birth defects have higher mortality and survivors are less likely to have a child. Fathers with birth defects are significantly more likely than unaffected fathers to have an affected child.

PMID:
11176913
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk