Johns Hopkins Med J. 1975 Mar;136(3):132-6.

Polycythemia produced by hemoglobin Osler (beta-145 (HC2) Tyr yields Asp).

Abstract

Polycythemia in a black woman was associated with hemoglobin Osler. In this hemoglobin the tyrosine at the penultimate position of the beta chain is replaced by aspartic acid. As a result oxygen affinity of the hemoglobin is very high, heme-heme interaction is absent, and the influence of hydrogen ion and 2,3 diphosphoglycerate on oxygen affinity is attenuated.

PMID:: 1117598; [PubMed - indexed for MEDLINE]

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Cited by 3 PubMed Central articles

A proton nuclear magnetic resonance investigation of proximal histidyl residues in human normal and abnormal hemoglobins. A probe for the heme pocket. [Biophys J. 1982]
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Winslow RM, Swenberg ML, Gross E, Chervenick PA, Buchman RR, Anderson WF. J Clin Invest. 1976 Mar; 57(3):772-81.
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Polycythemia produced by hemoglobin Osler (beta-145 (HC2) Tyr yields Asp).
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Polycythemia produced by hemoglobin Osler (beta-145 (HC2) Tyr yields Asp).

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