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Pathol Oncol Res. 1997;3(2):135-138.

Polychondritis Terminating in Eosinophilic Leukemia.

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  • 1Semmelweis University of Medicine, 3rd Department of Internal Medicine, Budapest, Hungary.


We report here on a patient presenting with Relapsing Polychondritis (RP) two years before the diagnosis of Myelodysplasia (MDS) terminating in Eosinophilic Leukemia (EoL). The evolution of RP several etiology of RP in this patient. The terminal development of EoL in our case is assumed to represent clonal evolution caused by a second mutagenic event. The existence of autoimmune skin disorders in both the patient and his offspring (vitiligo and subacute cutaneous lupus erythematosus, respectively) implies that the coexistence of MDS and RP may have been caused by a functional disturbance of the immune system.

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