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Neurology. 2001 Feb 13;56(3):415-8.

Clinical trials in HIV-associated cognitive impairment: cognitive and functional outcomes.

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  • 1Department of Neurology, University of Rochester, NY, USA.


Cognitive and functional outcomes are of primary interest in the design of efficacy trials in HIV-associated cognitive impairment. In a longitudinal cohort study, weak associations were found between measures of cognitive performance and commonly used measures of daily functioning (mostly self-report measures) in HIV-infected individuals. Modifications of current functional scales or new functional instruments are needed to assess the clinical relevance of cognitive changes in clinical trials of HIV-associated cognitive impairment.

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