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Biochem J. 2001 Feb 1;353(Pt 3):441-4.

An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds.

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  • 1Centre de Recherches sur l'Endocrinologie MolĂ©culaire et le DĂ©veloppement, CNRS, 9 rue Jules Hetzel, F-92190 Meudon, France.

Abstract

The cDNA of an uncoupling protein (UCP) homologue was obtained by screening a chicken skeletal-muscle library. The predicted 307-amino-acid sequence of avian UCP (avUCP) is 55, 70, 70 and 46% identical with mammalian UCP1, UCP2 and UCP3 and plant UCP respectively. avUCP mRNA expression is restricted to skeletal muscle and its abundance was increased 1.3-fold in a chicken line showing diet-induced thermogenesis, and 3.6- and 2.6-fold in cold-acclimated and glucagon-treated ducklings developing muscle non-shivering thermogenesis respectively. The present data support the implication of avUCP in avian energy expenditure.

PMID:
11171038
PMCID:
PMC1221587
[PubMed - indexed for MEDLINE]
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