Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Hum Genet. 2001 Feb;68(2):466-77. Epub 2001 Jan 19.

Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model.

Author information

  • 1Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. GSatten@cdc.gov

Abstract

We propose a novel latent-class approach to detect and account for population stratification in a case-control study of association between a candidate gene and a disease. In our approach, population substructure is detected and accounted for using data on additional loci that are in linkage equilibrium within subpopulations but have alleles that vary in frequency between subpopulations. We have tested our approach using simulated data based on allele frequencies in 12 short tandem repeat (STR) loci in four populations in Argentina.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk