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Eur J Haematol. 2001 Feb;66(2):137-9.

Treatment of T-prolymphocytic leukemia with nonmyeloablative allogeneic stem cell transplantation.

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  • 1Service d'Hématologie-Greffe de Moelle, Hôpital Saint Louis, Paris, France. laurent.garderet@sat.ap-hop-paris.fr

Abstract

AIM:

T-prolymphocytic leukemia (T-PLL) is a rare disease of the elderly characterized by a high white blood cell count and organomegaly, and is currently incurable. Our aim was to elicit graft-versus-leukemia reactions in a patient with T-PLL.

METHODS:

A 52-yr-old woman with refractory T-PLL underwent a nonmyeloablative regimen followed by allogeneic peripheral blood stem cell transplantation (a "minitransplant") from her HLA-matched sibling.

RESULTS:

There was no treatment related toxicity other than neutropenia. Engraftment was successful. The patient experienced no graft-versus-host disease (GVHD) at any time but, on day 84 after transplantation, had a relapse in the central nervous system. Despite infusion of donor lymphocytes and intralumbar chemotherapy, she died on day 157 of systemic disease.

CONCLUSION:

The reasons why treatment may have failed are discussed (nature of disease, disease progression, treatment schedule).

PMID:
11168523
[PubMed - indexed for MEDLINE]
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