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Curr Opin Chem Biol. 2001 Feb;5(1):67-73.

Recent advances in large-scale transposon mutagenesis.

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  • 1Paradigm Genetics Inc., 104 Alexander Drive, Building 2, Research Triangle Park, NC 27709, USA.


Transposons were identified as mobile genetic elements over fifty years ago and subsequently became powerful tools for molecular-genetic studies. Recently, transposon-mutagenesis strategies have been developed to identify essential and pathogenicity-related genes in pathogenic microorganisms. Also, a number of in vitro transposition systems have been used to facilitate genome sequence analysis. Finally, transposon mutagenesis of yeast and complex eukaryotes has provided valuable functional genomic information to complement genome-sequencing projects.

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